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Challenges in Diagnosing Cribriform Morular Thyroid Carcinoma
Jane Qu1, Mara Y Roth1, Mayumi Endo1
1Department of Medicine, University of Washington, Division of Endocrinology and Metabolism, Seattle, WA 98195, USA.
JCEM Case Reports
|June 11, 2025
Summary
Cribriform morular thyroid carcinoma (CMTC) is a rare cancer often linked to familial adenomatous polyposis (FAP). Early diagnosis is key, as CMTC can be the first sign of undiagnosed FAP.
Area of Science:
- Endocrinology
- Oncology
- Genetics
Background:
- Cribriform morular thyroid carcinoma (CMTC) is a rare thyroid malignancy.
- CMTC is strongly associated with familial adenomatous polyposis (FAP), with about 50% of cases linked to FAP.
- CMTC can be the initial presenting symptom in individuals with undiagnosed FAP.

