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Hyperthyroidism I: Introduction

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Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...

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Related Experiment Video

Updated: May 5, 2026

Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration

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Challenges in Diagnosing Cribriform Morular Thyroid Carcinoma.

Jane Qu¹, Mara Y Roth¹, Mayumi Endo¹

¹Department of Medicine, University of Washington, Division of Endocrinology and Metabolism, Seattle, WA 98195, USA.

JCEM Case Reports

|June 11, 2025

Summary

Cribriform morular thyroid carcinoma (CMTC) is a rare cancer often linked to familial adenomatous polyposis (FAP). Early diagnosis is key, as CMTC can be the first sign of undiagnosed FAP.

Area of Science:

Endocrinology
Oncology
Genetics

Background:

Cribriform morular thyroid carcinoma (CMTC) is a rare thyroid malignancy.

Keywords:

TI-RADS scoring cribriform morular thyroid carcinoma familial adenomatous polyposis thyroid nodules

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CMTC is strongly associated with familial adenomatous polyposis (FAP), with about 50% of cases linked to FAP.

CMTC can be the initial presenting symptom in individuals with undiagnosed FAP.