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MBaFus: A Virtual Lab of Microbubble-Augmented Focused Ultrasound for Noninvasive Tumor Ablation Based on Two-Way
Jingsen Ma1, Chao-Tsung Hsiao1, Aswin Gnanaskandan1,2
1Dynaflow, Inc., 10921-A Pump House Road, Annapolis Junction, MD 20701.
Journal of Medical Devices
|June 11, 2025
Summary
A new virtual lab uses advanced computation to predict focused ultrasound (FUS) and microbubble (MB) interactions for noninvasive tumor ablation. This tool shows promise for accelerating the clinical use of microbubble-augmented FUS (MBaFus) therapy.
Area of Science:
- Biomedical Engineering
- Acoustic Physics
- Computational Modeling
Background:
- Focused ultrasound (FUS) with microbubbles (MBs) offers noninvasive tumor ablation but faces clinical hurdles due to complex parameter dependencies.
- Accurate prediction of acoustic and thermal fields is crucial for optimizing microbubble-augmented FUS (MBaFus) treatments.
Purpose of the Study:
- To develop and validate a computational virtual lab for predicting MBaFus treatments.
- To assess the potential of this platform for accelerating clinical translation of noninvasive tumor ablation therapies.
Main Methods:
- Developed a two-way coupled Euler-Lagrange computation platform to model individual MB physics and nonlinear interactions.
- Implemented numerical algorithms and high-performance computing for predicting acoustic and thermal fields.
- Validated predictions against in vitro experiments and conducted ex vivo studies on porcine liver.
Main Results:
- The virtual lab accurately predicts acoustic and thermal fields for MBaFus.
- Ex vivo studies showed satisfactory agreement between numerical predictions and experimental measurements.
- MB augmentation effects on treatment outcomes were evaluated under varying MB conditions.
Conclusions:
- The developed numerical platform shows potential as a virtual lab for MBaFus.
- This tool can aid in optimizing noninvasive tumor ablation strategies.
- Further validation is needed, but initial results are promising for clinical adoption.
