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Updated: Jun 12, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

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Published on: December 6, 2016

Mandibular Advancement Devices for Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis.

E Günel¹, H M Kurtulmus², H Boyacioglu³

¹Department of Prosthodontics, Istanbul Aydin University Faculty of Dentistry, 34295 Istanbul, Turkey.

The European Journal of Prosthodontics and Restorative Dentistry

|June 11, 2025

Summary

This summary is machine-generated.

Mandibular advancement devices (MADs) effectively treat Obstructive Sleep Apnea (OSA) by reducing the apnea-hypopnea index (AHI) and improving minimum oxygen saturation (min SpO2). Age influences treatment outcomes, but body mass index (BMI) does not significantly impact effectiveness.

Keywords:

Clinical Trials Mandibular Advancement Devices Meta-Analysis Obstructive Sleep Apnea

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Area of Science:

Sleep Medicine
Respiratory Medicine
Biomedical Engineering

Background:

Obstructive Sleep Apnea (OSA) is a prevalent condition affecting sleep quality and cardiovascular health.
Mandibular Advancement Devices (MADs) are a common treatment modality for OSA.
The influence of patient-specific factors like age and BMI on MAD efficacy requires further investigation.

Purpose of the Study:

To systematically review and meta-analyze the effectiveness of MADs in treating OSA.
To assess the impact of age and body mass index (BMI) on key treatment outcomes: apnea-hypopnea index (AHI) and minimum oxygen saturation (min SpO2).

Main Methods:

Comprehensive literature search of PubMed and Google Scholar (January 2013 - January 2023).
Systematic screening and risk of bias assessment by two independent reviewers.
Meta-analysis of 13 selected studies to quantify treatment effects.

Main Results:

MADs demonstrated a significant reduction in AHI (mean difference: 15.75, p<0.00001).
Significant improvement in minimum SpO2 was observed post-treatment (mean difference: -3.70, p<0.00001).
Age was found to have a notable impact on treatment outcomes, while BMI did not show a significant effect.

Conclusions:

MADs are effective in reducing OSA severity (AHI) and improving oxygenation (min SpO2).
Patient age is a significant factor influencing the effectiveness of MAD therapy.
Further research may explore age-specific treatment protocols for MADs in OSA management.