[Biospecific sorbent for removal of proteinases from biological fluids]

Sorbents for removal of proteases from biological fluids were synthesized via immobilization of a specific protease inhibitor-ovomucoid from whites of duck eggs--in the bulk of polymeric hydrogel. The sorbents were shown to exhibit high capacity and selectivity in the removal of proteases from the model protein-containing solutions, blood plasma and blood. The sorbents did not affect the blood cells as well as the blood-clotting system. The sorbents were demonstrated to be effective in the removal of proteases from canine blood in acute pancreatitis.