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Moss Extracts as Natural Neuroprotective Agents: Mitigating LPS-Induced Neuroinflammation and Microglial Activation
Tijana D Stojanović1,2,3, Marija R Rakić2, Marija V Ćosić3
1Public Company "Nuclear Facilities of Serbia", 11000 Belgrade, Serbia.
Cells
|June 11, 2025
Summary
Moss extracts show potential for treating neurodegenerative diseases. These natural compounds exhibit significant anti-neuroinflammatory and neuroprotective effects by reducing harmful molecules and protecting cells.
Area of Science:
- Pharmacognosy and Neurobiology
- Natural Product Chemistry
Background:
- Neuroinflammation is a key factor in neurodegenerative diseases.
- Natural compounds are being explored for neuroprotective and anti-neuroinflammatory properties.
Purpose of the Study:
- To evaluate the neuroprotective and anti-neuroinflammatory potential of extracts from five moss species.
- To identify bioactive compounds in moss extracts.
Main Methods:
- Phytochemical profiling of moss extracts.
- In vitro assays including acetylcholinesterase (AChE) and tyrosinase inhibition.
- Cell-based assays measuring cell viability, reactive oxygen species (ROS), nitric oxide (NO), and inflammatory cytokines (IL-6, TNF-α) in BV2 microglia and SH-SY5Y cells.
Main Results:
- Moss extracts, particularly ethanolic ones, demonstrated significant acetylcholinesterase (AChE) inhibition.
- Extracts suppressed lipopolysaccharide (LPS)-induced production of ROS, NO, IL-6, and TNF-α in BV2 cells.
- Moss extracts reduced microglia-mediated neurotoxicity in SH-SY5Y cells and maintained high cell viability in BV2 and L929 cells.
Conclusions:
- Moss-derived extracts possess promising anti-neuroinflammatory and neuroprotective properties.
- These findings support further research into mosses as a source for natural therapeutics against neurodegenerative diseases.
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