Naples Prognostic Score Predicts New-Onset Atrial Fibrillation in Patients with ST-Elevated Myocardial Infarction...

Area of Science:

• Cardiology
• Internal Medicine
• Biomarkers

Background:

• New-onset atrial fibrillation (NOAF) is a common complication in ST-segment elevated myocardial infarction (STEMI) patients post-primary percutaneous coronary intervention (pPCI).
• Inflammation has been implicated as a predictor of NOAF.
• The Naples Prognostic Score (NPS) is a novel marker assessing inflammation and nutritional status.

Purpose of the Study:

• To evaluate the predictive capability of the NPS for NOAF in STEMI patients undergoing pPCI.
• To determine if NPS can serve as an independent predictor of NOAF.

Main Methods:

• 1537 STEMI patients undergoing pPCI were enrolled.
• Patients were categorized into NOAF and sinus rhythm (RSR) groups.
• Univariate and multivariate analyses identified predictors of NOAF, with p<0.05 considered significant.

Main Results:

• NOAF occurred in 7.74% of patients.
• Higher mean age and NPS were observed in the NOAF group (p<0.001 and p=0.008, respectively).
• Multivariate analysis identified age, NPS, and left atrial dimensions as independent predictors of NOAF.

Conclusions:

• The NPS is an independent predictor of NOAF in STEMI patients, alongside age and left atrial dimensions.
• The NPS, reflecting inflammatory burden, may assist in predicting NOAF incidence.
• This score could guide therapies targeting post-myocardial infarction inflammation.