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Left Ventricular and Atrial Function in Patients With Isolated Mitral Annular Calcification.
Kyu Kim1, Seo-Yeon Gwak1, Hyun-Jung Lee1
1Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Summary
Speckle-tracking echocardiography effectively assesses left ventricular (LV) and left atrial (LA) function in mitral annular calcification (MAC) patients. Impaired LV global longitudinal strain (GLS) and LA reservoir strain predict adverse cardiovascular outcomes.
Area of Science:
- Cardiology
- Echocardiography
- Cardiac Imaging
Background:
- Mitral annular calcification (MAC) poses challenges for evaluating left ventricular (LV) and left atrial (LA) function via Doppler echocardiography.
- This study focuses on isolated MAC, excluding patients with atrial fibrillation or significant valve disease.
Purpose of the Study:
- To determine the clinical significance of LV and LA function assessed by speckle-tracking echocardiography in patients with isolated MAC.
- To evaluate the predictive value of LV global longitudinal strain (GLS) and LA reservoir strain for adverse cardiovascular events.
Main Methods:
- Retrospective analysis of 275 patients with MAC identified between 2012-2016.
- LV global longitudinal strain (GLS) and LA reservoir strain were measured using vendor-independent software.
- Primary outcome: composite of cardiovascular death and heart failure admission, with a median follow-up of 42 months.
Main Results:
- Patients experiencing adverse events had significantly lower absolute values of LV-GLS and LA reservoir strain.
- Both LV-GLS and LA reservoir strain demonstrated a worsening trend with increasing MAC severity.
- LV-GLS and LA reservoir strain were independently associated with adverse outcomes and provided incremental predictive value over traditional measures.
Conclusions:
- Speckle-tracking echocardiography assessment of LV-GLS and LA reservoir strain is clinically valuable in patients with MAC.
- These echocardiographic parameters aid in predicting adverse cardiovascular outcomes in this patient population.
- The findings support the use of advanced echocardiographic techniques for risk stratification in MAC.
Keywords:
Left atrial strainLeft ventricular global longitudinal strainMitral annular calcificationOutcomeSpeckle-tracking echocardiographyMore Related Videos
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