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Challenges in managing Stewart-Treves Syndrome: navigating complexities in recurrent lymphangiosarcoma
Tanvi Rao1, Joseph Thomas2, Harshavardhan Kushal Shetty2
1Department of Plastic Surgery, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India tanvi.rao@manipal.edu.
BMJ Case Reports
|June 11, 2025
Summary
Stewart-Treves syndrome, a rare cancer, presents surgical challenges. This case report details managing recurrent lymphangiosarcoma after mastectomy and limb disarticulation.
Area of Science:
- Oncology
- Surgical Pathology
- Medical Case Reports
Background:
- Stewart-Treves syndrome (STS) is a rare, aggressive angiosarcoma.
- STS typically arises secondary to chronic lymphedema, often post-mastectomy.
- It carries a poor prognosis due to high recurrence and metastasis rates.
Purpose of the Study:
- To highlight the surgical complexities in managing STS.
- To present a case of recurrent angiosarcoma following treatment for breast cancer.
Main Methods:
- A case report of a female patient in her 60s is presented.
- The patient underwent modified radical mastectomy and adjuvant therapy for breast carcinoma.
- She subsequently developed STS, requiring limb disarticulation and further surgical intervention for recurrence.
Main Results:
- The patient developed recurrent angiosarcoma at the amputation site 6 months post-disarticulation.
- Surgical management included wide local excision and reconstruction with a free anterolateral thigh flap.
Conclusions:
- Managing recurrent STS poses significant surgical challenges.
- Multidisciplinary approaches and advanced reconstructive techniques are crucial for optimal outcomes in complex cases.

