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Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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Positron Emission Tomography01:29

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
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A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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Related Experiment Video

Updated: Jun 13, 2025

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
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PET/MR Imaging in Head and Neck Cancer.

Minerva Becker1, Claudio de Vito2, Nicolas Dulguerov3

  • 1Diagnostic Department, Division of Radiology, Unit of Head and Neck and Maxillofacial Radiology, Geneva University Hospitals, University of Geneva, Rue Gabrielle-Perret-Gentil 4, Geneva 14 1211, Switzerland.

PET Clinics
|June 11, 2025
PubMed
Summary
This summary is machine-generated.

Positron emission tomography/magnetic resonance (PET/MR) imaging is superior for detecting residual or recurrent head and neck squamous cell carcinoma (HNSCC) after therapy. PET/MR and PET/CT detect distant metastases equally well.

Keywords:
Diffusion-weighted imagingHead and neck cancerMR imagingPET/MR imagingStaging

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Author Spotlight: Standardizing Mouse In Vivo PET Imaging with Body Conforming Molds and Automated Analysis
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Area of Science:

  • Oncology
  • Radiology
  • Medical Imaging

Background:

  • Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignancy.
  • Current imaging modalities for HNSCC include hybrid PET/MR systems or sequential PET/CT and MR imaging.
  • MR imaging offers superior soft tissue characterization compared to CT.

Purpose of the Study:

  • To evaluate the utility of PET/MR imaging compared to PET/CT for assessing locoregional and distant disease in HNSCC.
  • To determine the optimal imaging technique for post-therapy surveillance of HNSCC.

Main Methods:

  • Comparison of hybrid PET/MR imaging with sequential PET/CT and MR imaging.
  • Utilizing advanced MR sequences such as perfusion and diffusion-weighted imaging.
  • Assessment of tumor and surrounding tissues for residual or recurrent disease.

Main Results:

  • PET/MR imaging demonstrates superiority in detecting locoregional residual/recurrent HNSCC due to enhanced soft tissue analysis.
  • MR imaging interpretation is improved when combined with PET data.
  • PET/MR imaging and PET/CT show comparable performance in detecting distant metastases and second primary tumors.

Conclusions:

  • PET/MR imaging is the preferred modality for assessing locoregional residual/recurrent HNSCC post-therapy.
  • Both PET/MR and PET/CT are effective for detecting distant HNSCC metastases.
  • Advanced MR techniques significantly contribute to the diagnostic accuracy of PET/MR in HNSCC.