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Advances of Cell Printing Technology in Organoid Engineering
Yu-Han Ho1, Yuanhong Liao2, Lingni Liao2
1Pharmaceutical Analysis, Fudan University School of Pharmacy, Shanghai, China.
Tissue Engineering. Part B, Reviews
|June 12, 2025
Summary
Cell printing, or bioprinting, advances organoid engineering for disease modeling and personalized medicine. This technology creates complex 3D tissues for drug testing and transplantation, showing great promise in biomedical research.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Tissue Engineering
Background:
- Organoid engineering creates 3D structures mimicking organ function for research.
- Cell printing (bioprinting) enables precise deposition of living cells for complex tissue generation.
- Bioinks facilitate the creation of in vitro tissues for studying morphogenesis and disease.
Purpose of the Study:
- To summarize recent advances in cell printing technology for organoid development.
- To explore applications in patient-specific tissue grafts and drug testing.
- To highlight the potential of bioprinted organoids in clinical settings and precision medicine.
Main Methods:
- Review of recent literature on cell printing and organoid engineering.
- Analysis of bioprinting technologies for cell and organoid printing.
- Discussion of applications in disease modeling, drug screening, and transplantation.
Main Results:
- Cell printing technology enables the development of diverse organoid models.
- Bioprinted organoids and tissue grafts show promise in drug testing and disease progression studies.
- Some bioprinted organoids have advanced to clinical trials, demonstrating translational potential.
Conclusions:
- The integration of cell printing and organoid engineering offers significant potential for biomedical research.
- Bioprinting technologies are crucial for developing advanced organoid models and patient-specific therapies.
- Cell printing is poised to revolutionize tissue transplantation and precision medicine.
