Related Experiment Video
Updated: Jun 14, 2025
Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
Published on: July 12, 2018
Structural Alterations in Diverticular Disease
Kerri Lopez1, Lillias H Maguire2,3
1Division of Colon and Rectal Surgery, Department of Surgery, University of Maryland, Baltimore, Maryland.
Abstract:
Clinicians appreciate the structural alterations of diverticular disease when navigating narrow, angulated colons with a colonoscope or removing stiff, fixed sigmoid colons at surgery. Investigation of these tissues reveals increased thickness of smooth muscle, alterations in the amount and structure of the extracellular matrix, and changes to the motility of the colon. More sophisticated technologies now allow scientists to unravel the connections between these alterations and the individual genetic background. This article explores the structural alterations of diverticular disease including collagen, smooth muscle, the enteric nervous system, and the interstitial cells of Cajal.
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