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Biocompatible Multi-functional Polymeric Material for Mineralized Tissue Adhesion.

Yan Luo1, Chenyang Zhang2, Sage Fulco1

  • 1Mechanical Engineering and Applied Mechanics, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, United States.

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PubMed
Summary
This summary is machine-generated.

This study created a new biocompatible dental adhesive resin. It enhances dentin adhesion and mechanical strength, offering a safer alternative to conventional dental materials.

Keywords:
Triacrylate resindentin adhesionmolecular dynamics simulationnanoindentationthiol-ene polymerization

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Area of Science:

  • Biomaterials Science
  • Dental Materials Science
  • Polymer Chemistry

Background:

  • Dental adhesive resins are crucial for composite restoration longevity.
  • Conventional systems can lead to cytotoxic residual monomers due to inhomogeneous networks.
  • Protecting dental pulp cells from monomer leakage is essential.

Purpose of the Study:

  • To develop a biocompatible, multifunctional thiol-ene resin system for improved dentin adhesion.
  • To enhance mechanical properties and reduce cytotoxicity in dental adhesives.
  • To investigate the efficacy of incorporating trimethylolpropane triacrylate (TMPTA) and bis[2-(methacryloyloxy)ethyl] phosphate (BMEP).

Main Methods:

  • Utilized molecular dynamics simulations to determine optimal resin ratios.
  • Conducted rheological and mechanical tests to assess material properties.
  • Performed shear bond strength tests and nanoindentation modulus mapping on dentin.
  • Evaluated in vitro biocompatibility with fibroblast cells.

Main Results:

  • An optimal triacrylate:trithiol ratio of 2.5:1 was identified via simulations.
  • The resin system exhibited a storage modulus of ~30 MPa.
  • Addition of BMEP significantly improved dentin adhesion, reaching 10.8 MPa shear bond strength.
  • The triacrylate-BMEP resin demonstrated in vitro biocompatibility.

Conclusions:

  • The developed triacrylate-trithiol crosslinking and BMEP chemophysical bonding enhance bond strength.
  • The new resin system offers improved biocompatibility for dental applications.
  • This multifunctional resin system presents a promising advancement in dental adhesive technology.