Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

184
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
184
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

478
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
478
High-Level and Low-Level Awareness01:19

High-Level and Low-Level Awareness

252
Controlled processes in human consciousness represent high-alert mental states where individuals deliberately focus their attention on achieving specific goals. Controlled processes can be seen in situations like mastering new technology, where a person might become so absorbed that they ignore surrounding distractions. Such processes involve selective attention, requiring one to concentrate on particular elements of experience while disregarding others. These are governed by executive...
252
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

387
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
387
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

697
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
697

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Commonality and variability in functional networks in children under 5 years old.

Communications biology·2026
Same author

Shared and specific associations of amygdala nuclei volumes with PTSD symptom domains and childhood trauma: An ENIGMA-PGC PTSD mega-analysis.

Molecular psychiatry·2026
Same author

Erratum: "Tract-specific white matter microstructure associated with early cognitive development in infants" [Neuroimage Rep 6 (2026) 100336].

Neuroimage. Reports·2026
Same author

An open, fully-processed data resource for studying mood and sleep variability in the developing brain.

Aperture neuro·2026
Same author

Frame-wise multi-echo distortion correction for superior functional MRI.

Imaging neuroscience (Cambridge, Mass.)·2026
Same author

Trajectories of hippocampal subregion development in the first years of life and their association with school-aged episodic memory outcomes.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Jun 13, 2025

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents
09:01

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

12.5K

Less is More: Lower Levels of Task-Induced Hippocampal Activation Predict Better Performance on a Separate Verbal

Caitlin A Sisk1,2, Kathleen B McDermott3,4, Jed T Elison1,2,5

  • 1Department of Pediatrics, University of Minnesota, Minneapolis, MN 55454.

Biorxiv : the Preprint Server for Biology
|June 12, 2025
PubMed
Summary

This study replicated a key finding: greater posterior hippocampus (pHPC) activation during learning correlates with poorer verbal memory performance. This confirms a reliable link between pHPC activity and memory abilities.

Keywords:
hippocampuslearningmemoryparietal memory networkreplication

More Related Videos

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

14.8K
Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion
15:57

Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion

Published on: May 4, 2011

16.3K

Related Experiment Videos

Last Updated: Jun 13, 2025

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents
09:01

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

12.5K
Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

14.8K
Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion
15:57

Brain Imaging Investigation of the Memory-Enhancing Effect of Emotion

Published on: May 4, 2011

16.3K

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Memory Research

Background:

  • Hippocampal subregions (posterior and anterior) differentially support memory based on content and duration.
  • Individual differences in hippocampal activation predict memory abilities.
  • Replication is crucial to validate findings on neurobiological associations in memory.

Purpose of the Study:

  • To replicate the negative relationship between posterior hippocampus (pHPC) activation and verbal memory performance.
  • To confirm the reliability of observed associations between hippocampal activity and memory abilities.
  • To advance understanding of how the pHPC supports verbal memory.

Main Methods:

  • Replicated a previous study's findings in an independent sample of 86 participants.
  • Measured task-induced activation in the posterior hippocampus (pHPC) during a Lithuanian word learning task.
  • Assessed out-of-scanner verbal memory performance using the California Verbal Learning Test (CVLT-II).

Main Results:

  • A significant negative correlation was identified between pHPC activation during word learning and CVLT-II performance.
  • This finding replicates the relationship reported by Wig et al. (2008).
  • The replication confirms the reliability of the observed negative association.

Conclusions:

  • The posterior hippocampus (pHPC) plays a reliable role in supporting verbal memory.
  • Task-induced activation in the pHPC is negatively associated with verbal memory performance.
  • This replication is a critical step toward understanding the functional neuroanatomy of verbal memory.