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A case of primary pulmonary synovial sarcoma
Keigo Ozono1, Keita Sakanashi1, Naoya Iwamoto1
1Department of Surgery and Oncology, Kyushu University, Fukuoka, Japan.
Respiratory Medicine Case Reports
|June 12, 2025
Summary
Primary pulmonary synovial sarcoma (PPSS) is a rare lung cancer that can mimic benign tumors. This case shows the importance of pathology for diagnosis and successful surgical treatment.
Area of Science:
- Pulmonology
- Oncology
- Pathology
Background:
- Primary pulmonary synovial sarcoma (PPSS) is an exceptionally rare lung malignancy.
- PPSS presents diagnostic challenges, often mimicking benign lung tumors on imaging.
Observation:
- A 46-year-old woman presented with a right lower lobe lung nodule with low FDG uptake on PET, suggesting a benign lesion.
- Initial imaging findings were misleading, raising suspicion for a benign condition.
Findings:
- Histopathology confirmed primary pulmonary synovial sarcoma after wedge resection.
- Surgical resection with clear margins was performed, followed by a right lower lobectomy.
Implications:
- This case underscores the difficulty in differentiating PPSS from benign lung lesions using imaging alone.
- Pathological confirmation is crucial for accurate diagnosis and management of PPSS.
- Further case accumulation is necessary to establish standardized treatment strategies for PPSS.
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