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Role of the Small Intestinal Microbiota in Gastrointestinal Disorders
Jungnam Kwon1, Dong Han Yeom2, Moon Yong Lee3
1Department of Surgery, Wonkwang University School of Medicine, Iksan, Korea.
Summary
The small intestinal microbiota is vital for gut health but understudied. This review covers its composition, role in disorders like SIBO, and the impact of PPIs on microbial balance.
Area of Science:
- Gastroenterology
- Microbiology
- Microbiome Research
Background:
- The small intestinal microbiota's role in health and disease is critical.
- Research is limited due to methodological challenges in studying the small intestine.
- Understanding this microbiota is key to addressing gastrointestinal disorders.
Purpose of the Study:
- To review the taxonomic composition, microbial load, and diversity of the normal small intestinal microbiota.
- To highlight the involvement of small intestinal microbiota in gastrointestinal disorders.
- To discuss the implications of proton pump inhibitors (PPIs) on small intestinal microbiota.
Main Methods:
- Literature review of existing studies on small intestinal microbiota.
- Analysis of taxonomic composition, microbial load, and diversity.
- Examination of the role in functional dyspepsia, small intestinal bacterial overgrowth (SIBO), and NSAID-enteropathy.
Main Results:
- The small intestinal microbiota exhibits specific taxonomic profiles, loads, and diversity.
- Dysbiosis is implicated in functional dyspepsia, SIBO, and NSAID-induced enteropathy.
- Proton pump inhibitors significantly impact small intestinal microbiota, leading to dysbiosis.
Conclusions:
- Small intestinal microbiota plays a significant role in gastrointestinal health and disease.
- Further research into both luminal and mucosal microbiota is needed.
- Judicious use of acid suppressants like PPIs is crucial in clinical practice.
Keywords:
Anti-inflammatory agent, non-steroidalDyspepsiaIntestine, smallMicrobiotaSmall intestinal bacterial overgrowthMore Related Videos
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