Related Experiment Video
Updated: Jun 14, 2025
11:19
Robotic Myotomy and Partial Fundoplication for Achalasia
Published on: August 11, 2023
1.4K
[Sex/Gender Differences in Esophageal Motility Disorders]
Summary
Esophageal motility disorders affect men and women differently. Research is needed to understand sex and gender differences in treatment outcomes for conditions like achalasia.
Area of Science:
- Gastroenterology and Neurogastroenterology
- Esophageal Physiology
- Sex and Gender Differences in Medicine
Context:
- Esophageal motility disorders (EMDs) stem from nerve imbalances in the esophagus.
- Common EMDs include achalasia, distal esophageal spasms, and jackhammer esophagus.
- While achalasia affects sexes equally, hypermotility disorders are more prevalent in women.
Purpose:
- To highlight existing knowledge on sex and gender differences in EMDs.
- To identify gaps in research regarding peroral endoscopic myotomy (POEM) outcomes.
- To emphasize the need for sex-tailored treatment strategies for EMDs.
Summary:
- Women with achalasia report more chest pain and respond better to pneumatic dilatation than men.
- Men with achalasia may present with higher lower esophageal sphincter pressure.
- Data on sex and gender differences in POEM outcomes for EMDs is currently insufficient.
Impact:
- Future research can elucidate sex-specific outcomes and complications of EMD treatments.
- Findings will inform the development of personalized, sex-tailored therapeutic approaches.
- Optimizing EMD treatment requires understanding and addressing sex and gender variations.
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