Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

520
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
520
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

2.5K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.5K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ATACdb 2.0: a comprehensive chromatin accessibility database of human and mouse.

Nucleic acids research·2025
Same author

scVMAP: a comprehensive platform for integrating single-cell chromatin accessibility regions with causal variants.

Nucleic acids research·2025
Same author

SpatialRef: a reference of spatial omics with known spot annotation.

Nucleic acids research·2024
Same author

Metal- and light-free decarboxylative direct C-H alkylation of heteroarenes at room temperature.

Organic & biomolecular chemistry·2024
Same author

Synthesis and antitumor activity of erysolin and its metabolites.

Journal of Asian natural products research·2022
Same author

Six New neo-Clerodane Diterpenoids from Aerial Parts of Scutellaria barbata and Their Cytotoxic Activities.

Planta medica·2018
Same journal

MetaphorPrompt2-A Structure and Function-Focused Approach for Extracting Causal Events from Biological Text.

Computational and structural biotechnology journal·2026
Same journal

Microbiome-Metabolome Crosstalk in HPV Pathogenesis: From Ecosystem Dynamics to Translational Biomarkers.

Computational and structural biotechnology journal·2026
Same journal

Minimum-Cost Synthetic Genome Planning: An Algorithmic Framework.

Computational and structural biotechnology journal·2026
Same journal

Functional Genomic Evidence for Candidate Small Viral RNA-Mediated Epigenetic Interference in SARS-CoV-1 and SARS-CoV-2.

Computational and structural biotechnology journal·2026
Same journal

From Pixels to Patterns: A Multidimensional Framework to Decode Cytoskeletal Organization.

Computational and structural biotechnology journal·2026
Same journal

A Large Concept Model for Mechanistic Simulation of Disease Trajectories: A Hypothesis-Generating Exemplar for Pediatric Acute Lymphoblastic Leukemia.

Computational and structural biotechnology journal·2026
See all related articles

Related Experiment Video

Updated: Jun 14, 2025

Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis
07:11

Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis

Published on: November 10, 2023

2.2K

DiabetesOmic: A comprehensive multi-omics diabetes database.

Fu-Hong Cai1,2,3,4,5, Feng-Cui Qian1,4,5, Bing-Long Li4

  • 1The First Affiliated Hospital & Hunan Provincial Key Laboratory of Multi-omics And Artificial Intelligence of Cardiovascular Diseases, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, China.

Computational and Structural Biotechnology Journal
|June 12, 2025
PubMed
Summary
This summary is machine-generated.

DiabetesOmic is a new database integrating multi-omics data for type 1 and type 2 diabetes. It provides valuable molecular insights into diabetes pathogenesis and complications for researchers.

Keywords:
DiabetesMulti-omicsSingle cell

More Related Videos

Author Spotlight: Multi-Layered Approach to Understand Postnatal Functions of Pancreatic Islets in Non-Human Primates
03:39

Author Spotlight: Multi-Layered Approach to Understand Postnatal Functions of Pancreatic Islets in Non-Human Primates

Published on: November 8, 2024

481
A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases
06:50

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases

Published on: May 29, 2020

2.5K

Related Experiment Videos

Last Updated: Jun 14, 2025

Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis
07:11

Author Spotlight: Emerging Technologies and Advanced Tools for Decoding Metabolomics Data Analysis

Published on: November 10, 2023

2.2K
Author Spotlight: Multi-Layered Approach to Understand Postnatal Functions of Pancreatic Islets in Non-Human Primates
03:39

Author Spotlight: Multi-Layered Approach to Understand Postnatal Functions of Pancreatic Islets in Non-Human Primates

Published on: November 8, 2024

481
A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases
06:50

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases

Published on: May 29, 2020

2.5K

Area of Science:

  • Genomics and Bioinformatics
  • Molecular Biology
  • Endocrinology

Background:

  • Diabetes mellitus involves complex molecular mechanisms.
  • Multi-omics sequencing advances understanding of diabetes pathogenesis.
  • A need exists for integrated molecular resources in diabetes research.

Purpose of the Study:

  • To present DiabetesOmic, a comprehensive multi-omics database for diabetes research.
  • To collect and analyze transcriptional regulatory information from diverse sequencing data.
  • To enhance translational relevance through curated clinical complication annotations.

Main Methods:

  • Integrated five high-throughput sequencing modalities: ChIP-seq, RNA-seq, ATAC-seq, scATAC-seq, and scRNA-seq.
  • Collected and quality-assessed 487 diabetes samples (Type 1 and Type 2) across multiple tissues.
  • Developed specific analytical pipelines for regulatory network, gene expression, chromatin accessibility, and transcription factor analyses.

Main Results:

  • DiabetesOmic database established with extensive multi-omics data.
  • Generated multi-dimensional transcriptional regulatory information.
  • Identified disease-associated regulatory elements, epigenetic modifications, and cell type-specific molecular signatures.

Conclusions:

  • DiabetesOmic serves as a valuable molecular resource for diabetes research.
  • Facilitates deeper investigation into diabetes pathology and progression.
  • Advances understanding of molecular mechanisms underlying diabetes and its complications.