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Biological Processes as Exploratory Dynamics.

Jane Kondev1, Marc Kirschner2, Hernan G Garcia3,4

  • 1Department of Physics, Brandeis University, Waltham, MA, U.S.A.

Arxiv
|June 12, 2025
PubMed
Summary
This summary is machine-generated.

Biological processes achieve high fidelity by using exploratory dynamics, where systems repeatedly try random trajectories until a specific final state is reached, unlike physics-based systems. This ensures successful outcomes regardless of initial conditions.

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Area of Science:

  • * Biological Dynamics
  • * Systems Biology
  • * Biophysics

Background:

  • * Many biological processes achieve specific functions through repeated, abortive dynamic trajectories.
  • * Microtubule attachment to kinetochores during cell division exemplifies this, with repeated growth and shrinkage cycles.
  • * This contrasts with physical and chemical processes where initial conditions dictate outcomes.

Purpose of the Study:

  • * To investigate the hypothesis that exploratory dynamics are essential for biological processes requiring a specific final state.
  • * To examine similarities across biological processes relying on random trajectories and subset selection for functional achievement.
  • * To quantitatively model and analyze exploratory dynamics in biological systems.

Main Methods:

  • * Review of the historical principles of dynamics in physics and biology.
  • * Analysis of biological phenomena exhibiting exploratory dynamics.
  • * Development and examination of quantitative models for exploratory dynamics, focusing on repeated trials leading to a successful outcome.

Main Results:

  • * Identified common features in biological processes that utilize exploratory dynamics to reach a specific functional state.
  • * Developed and analyzed models demonstrating how repeated trials increase the probability of achieving the desired final state.
  • * Explored the influence of microscopic parameters on exploratory dynamics and their associated energetic costs.

Conclusions:

  • * Exploratory dynamics represent a fundamental biological strategy for achieving high-fidelity outcomes when final states, not initial conditions, are critical.
  • * This dynamic approach allows biological systems to reliably reach specific functional goals through a process of trial and error.
  • * Understanding these dynamics offers insights into cellular mechanisms and potential targets for manipulating biological processes.