Related Experiment Video

Updated: Jun 15, 2025

Intratracheal Instillation of Stem Cells in Term Neonatal Rats
04:27

Intratracheal Instillation of Stem Cells in Term Neonatal Rats

Published on: May 4, 2020

5.6K

Efficacy of Intravenous Methylprednisolone Pulses in Children With Postinfectious Bronchiolitis Obliterans

Souad Ghattas1, David Drummond1,2, Alice Hadchouel1,2,3

  • 1AP-HP, Hôpital Universitaire Necker-Enfants Malades, Service de Pneumologie Pédiatrique, Centre de Référence pour les Maladies Respiratoires Rares de l'Enfant, Paris, France.

Pediatric Pulmonology
|June 12, 2025
PubMed

Insights

Intravenous methylprednisolone pulses did not improve outcomes for children with postinfectious bronchiolitis obliterans (PIBO). This retrospective study found no significant clinical or functional differences compared to untreated patients.

Area of Science:

  • Pediatric Pulmonology
  • Clinical Immunology

Background:

  • Postinfectious bronchiolitis obliterans (PIBO) is a severe obstructive lung disease in children.
  • Treatment options for PIBO remain limited, necessitating research into effective therapies.

Purpose of the Study:

  • To evaluate the efficacy of intravenous methylprednisolone pulses in managing PIBO in pediatric patients.
  • To compare clinical outcomes and lung function in treated versus untreated PIBO patients.

Main Methods:

  • Retrospective analysis of 31 pediatric PIBO patients.
  • Comparison of respiratory symptoms, exacerbations, hospitalizations, and lung function tests between methylprednisolone pulse recipients and a control group.
  • Subgroup analysis of the severest patients at diagnosis.

Main Results:

  • The methylprednisolone group experienced longer initial hospitalizations, more ICU admissions, and greater oxygen needs.
  • More patients in the treatment group required unscheduled hospitalizations within 6 months.
  • No significant differences in lung function tests or clinical evolution were observed between groups, even in the severest subgroup.

Conclusions:

  • Intravenous methylprednisolone pulses showed no benefit in the subsequent evolution of severe postinfectious bronchiolitis obliterans.
  • The findings suggest that this treatment strategy does not alter the disease course in PIBO patients.
Abstract

Keywords:
childrenchronic obstructive lung diseasesteroids

More Related Videos

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

7.9K
Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis06:03

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis

Published on: May 9, 2025

261

Related Concept Videos

Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
125
Inhaled Medications01:23

Inhaled Medications

Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
244
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
1.5K
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
188
Pneumonia IV: Management01:28

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
311
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
362