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Updated: May 12, 2026

Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles
Published on: January 22, 2015
Chitosan/PEG nanoparticle-embedded oleogels improve blueberry derived resveratrol bioavailability and antioxidant
Anika Singh1, Yigong Guo2, Maxine Cruz2
1Natural Health and Food Products Research Group, Centre for Applied Research and Innovation (CARI), British Columbia Institute of Technology, 4355 Mathissi Pl, Burnaby, BC V5G 4S8, Canada; Food, Nutrition, and Health, Faculty of Land & Food Systems. 2205 East Mall, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Abstract:
Blueberry polyphenols exhibit antioxidant and anti-inflammatory properties with a plausible role in preventing chronic diseases. However, applications in food or supplements is limited by low bioavailability. This study was aimed to formulate oleogel-blueberry extract encapsulated systems with chitosan/polyethylene glycol (PEG) nanoparticles (NPs) to enhance resveratrol delivery and bioavailability while retaining bioactivity. NPs were formulated via ionic gelation at pH 5.5 and mixed with soybean (SO), peanut (PO), or hemp oil (HO) to create solid oleogels containing 25 % or 32 % oil with lecithin and sitosterol. Rheological analysis confirmed solid-like properties. HO oleogels showed the highest resveratrol delivery (P < 0.05) and superior chemical stability. Resveratrol release from HO improved bioactive penetration and intracellular antioxidant capacity in cultured Caco-2 intestinal cells, with no toxicity observed. These findings support expanding oleogels as delivery vehicles for blueberry polyphenolics, like resveratrol.
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