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Updated: Jun 14, 2025

Author Spotlight: Elucidating the Dynamics of Mechano-Transduction and Nuclear Agitation in Mouse Oocytes
Published on: January 12, 2024
Impact of organelle architecture on oocyte developmental potential
Elvira Nikalayevich1, Noemi Zollo1, Marie-Hélène Verlhac1
1Center for Interdisciplinary Research in Biology (CIRB), Collège de France, Université PSL, CNRS, INSERM, 75005 Paris, France.
Abstract:
Oocytes are female gametes specialized in storing maternal RNAs, proteins, lipids, and metabolites essential for embryonic development after fertilization, sometimes for decades in humans. To support this extended lifespan, oocytes have evolved mechanisms to organize specialized organelles. This review highlights recent discoveries on how oocytes regulate mRNA and protein accumulation, storage, and degradation over time. Additionally, we explore advances in understanding cytoplasmic activity and remodeling, particularly the role of cortex mechanical properties in fine-tuning organelle distribution and function to ensure proper oocyte development.
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