Post-Stroke Rehabilitation: Neurophysiology Processes of Bilateral Movement Training and Interlimb Coupling-A...

Area of Science:

• Neuroscience
• Rehabilitation Medicine
• Biomedical Engineering

Background:

• Bilateral movement training (BMT) and interlimb coupling are promising neurorehabilitation strategies for stroke survivors.
• Optimal implementation and underlying mechanisms of BMT require further elucidation.
• This review synthesizes neurophysiological principles of BMT and interlimb coupling for stroke recovery.

Purpose of the Study:

• To explore neurophysiological principles of BMT and interlimb coupling in stroke rehabilitation.
• To identify effective bilateral and interlimb movement strategies for post-stroke recovery.
• To highlight research gaps and future directions in BMT for stroke survivors.

Main Methods:

• Systematic literature search (2014-2024) in PubMed, Cochrane, and Google Scholar.
• Inclusion of clinical trials on stroke survivors undergoing bilateral training.
• Data extraction on neurophysiological mechanisms, intervention characteristics, and clinical outcomes.

Main Results:

• BMT enhances motor recovery via central pattern generators, interhemispheric coupling, and cortical disinhibition.
• High-intensity BMT benefits moderate-to-severe impairments; low-intensity aids early recovery.
• Task-specific exercises, robotics, sensory enhancement, and VR show promise.

Conclusions:

• BMT and interlimb coupling are crucial for neural plasticity and motor coordination post-stroke.
• Integrating robotics, sensory enhancement, and VR with BMT maximizes rehabilitation potential.
• Future research needs personalized, technology-integrated, and longitudinal studies for optimized outcomes.