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Protocols of Thiamine Supplementation: Clinically Driven Rationality vs. Biological Commonsense
1Neurology Department, Hôpital Henri-Mondor, 1 Rue Gustave Eiffel, 94000 Créteil, France.
Journal of Clinical Medicine
|June 13, 2025
Summary
Neurology thiamine supplementation protocols often exceed biological requirements. Simplifying to a single 100 mg dose may be sufficient for treating thiamine deficiency.
Area of Science:
- Neurology
- Biochemistry
- Clinical Pharmacology
Background:
- Thiamine (Vitamin B1) deficiency can lead to severe clinical complications.
- Supplementation is crucial for preventing or reversing these effects.
- Current supplementation protocols in neurology require examination.
Purpose of the Study:
- To evaluate the appropriateness of current thiamine supplementation protocols in neurological practice.
- To compare recommended thiamine doses with biological requirements.
Main Methods:
- Systematic review of recommended thiamine supplementation protocols in neurology.
- Quantitative analysis of recommended dosages versus estimated whole-body thiamine stores.
Main Results:
- Recommended thiamine dosages significantly exceed biological requirements.
- Median daily intake and total supplementation amounts were 7.8-fold and 30.6-fold higher than whole-body stores, respectively.
- Protocols often involve high initial doses followed by tapering.
Conclusions:
- Current thiamine supplementation protocols in neurology are generally excessive.
- A simplified approach, potentially a single 100 mg dose administered early, may be biologically adequate.
- Further research could refine optimal thiamine dosing strategies.
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