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Intelligent Gene Delivery System Functionalized Metal Implants for Fracture Repair via Remodeling Mitochondrial

Gang Zheng1, Feng Hu1, Mengqian Wu1

  • 1Department of Orthopedics, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, P. R. China.

Advanced Healthcare Materials
|June 13, 2025
PubMed
Summary

This study developed a novel gene delivery system using diselenide-bridged mesoporous organosilica nanoparticles (SeMONs) to enhance fracture healing by improving bone marrow mesenchymal stem cells (BMSCs) function and restoring mitochondrial homeostasis.

Keywords:
diselenide‐bridged mesoporous organosilica nanoparticlesfracturegene therapymitochondriaosteogenesis

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