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Updated: Jun 14, 2025

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
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Peptide Display Directed Assembly of Biopolymer Core-Silica Shell Particles.

Deeptee Chandrashekhar Pande1, Frank Sainsbury1, Bernd H A Rehm1,2

  • 1Centre for Cell Factories and Biopolymers, Griffith Institute for Biomedicine and Glycomics, Griffith University, Nathan, QLD, 4111, Australia.

Advanced Healthcare Materials
|June 13, 2025
PubMed
Summary
This summary is machine-generated.

Engineered bacteria create biopolyester core-silica shell particles for enhanced drug delivery. These novel structures offer high payload capacity and silica-mediated protection, overcoming limitations of traditional silica capsules.

Keywords:
biopolymercellular uptakecurcumincytotoxicitypolyhydroxybutyratesilica shell

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Area of Science:

  • Biomaterials Engineering
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Silica capsules are of interest for active compound delivery due to their protective properties.
  • Limited cargo-loading capacity is a key challenge for silica capsules.
  • Biopolyester particles (BPs) offer potential as a core material for novel delivery systems.

Purpose of the Study:

  • To engineer Escherichia coli for assembling peptide-functionalized biopolyester particles (BPs).
  • To develop a biomimetic templating approach for creating BP core-silica shell structures.
  • To evaluate the payload capacity, stability, and biocompatibility of the novel core-shell structures for drug delivery.

Main Methods:

  • Engineering Escherichia coli to display RK1 peptide on biopolyester particles.
  • Utilizing peptide-coated BPs as templates for silica shell formation via precursor treatment.
  • Characterization using electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, and X-ray diffraction.
  • Assessing encapsulation efficiency of curcumin and in vitro cytotoxicity.

Main Results:

  • Successfully assembled submicrometer biopolyester particles displaying RK1 peptide.
  • Formed robust biopolyester core-silica shell structures with efficient silica shell formation (0.10 g silica/g BPs).
  • Achieved a 23.6% encapsulation efficiency for curcumin, significantly increasing payload capacity.
  • Demonstrated no cytotoxicity and efficient cellular uptake of the core-shell particles.

Conclusions:

  • Presents an innovative, environmentally benign method for creating biopolyester core-silica shell structures.
  • The developed structures offer enhanced drug payload capacity and silica-mediated protection.
  • These novel materials are suitable for controlled drug delivery applications.