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Updated: Jun 14, 2025

Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Phosphine-Catalyzed Modular Synthesis of (E)-Allyl Hydrazones, Tetrahydropyridazines, and Pyridazines
Xuehui Liang1, Ying Chen1, Jiecheng Ji2
1Guangxi Key Laboratory of Pharmaceutical Precision Detection and Screening, Guangxi Key Laboratory of Bioactive Molecules Research and Evaluation, and Key Laboratory of Micro-Nanoscale Bioanalysis and Drug Screening of Guangxi Education Department, Pharmaceutical College, Guangxi Medical University, Nanning 530021, China.
Abstract:
A novel phosphine-catalyzed three-component reaction has been developed for the efficient construction (E)-allyl hydrazones/oximes. This transformation proceeds with excellent chemo- and regioselectivity while exhibiting remarkable functional group tolerance and broad substrate scope. Biologically relevant tetrahydropyridazines and pyridazines could also be readily synthesized via allylation/6-endo-trig processes in either a stepwise or one-pot manner. The utility of this methodology is further demonstrated by the use of N-allyl (pyridin-2-yl)hydrazones as configurationally stable ligands for Ullmann C-N coupling.
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