Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

334
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
334
Cancer Therapies02:49

Cancer Therapies

7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
Actuarial Approach01:20

Actuarial Approach

68
The actuarial approach, a statistical method originally developed for life insurance risk assessment, is widely used to calculate survival rates in clinical and population studies. This method accounts for participants lost to follow-up or those who die from causes unrelated to the study, ensuring a more accurate representation of survival probabilities.
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
68
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.5K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing current diagnostic, staging, and treatment practices in community and academic centers for individuals with stage IB-IIIA non-small cell lung cancer.

Translational lung cancer research·2026
Same author

Rates of Systemic Treatment for Metastatic Non-Small Cell Lung Cancer Among Older Adults.

JAMA oncology·2026
Same author

Mindful self-compassion to reduce stigma among individuals diagnosed with lung cancer (MSC-LC): a pilot study protocol for a parallel-group, randomized controlled trial.

Pilot and feasibility studies·2026
Same author

Valued Living intervention to increase advance care planning and well-being in depressed and anxious adults with advanced cancer: Randomized trial in community oncology clinics.

Cancer·2026
Same author

Quality Implementation of Lung Cancer Screening System: A System to Support High-Quality Delivery of Lung Cancer Screening in Diverse Settings.

Chest·2026
Same author

Lung cancer screening: are race- and risk-aware criteria needed?

Journal of the National Cancer Institute·2026

Related Experiment Video

Updated: Jun 14, 2025

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

226

Writing Content Predicts Outcomes in Written Exposure to Worst-Case Scenarios for Advanced Cancer.

Lauren B Finkelstein1, Christopher P Wojdak1, Jamie L Studts2,3

  • 1Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado, USA.

Journal of Palliative Medicine
|June 13, 2025
PubMed
Summary

This study explored how writing about worst-case cancer scenarios impacts distress. Linguistic analysis revealed specific word use patterns correlating with reduced trauma and fear of cancer progression.

Keywords:
cancerexposure therapyfear of cancer progressionpsycho-oncologytraumawriting

More Related Videos

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

7.2K
Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.2K

Related Experiment Videos

Last Updated: Jun 14, 2025

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

226
Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

7.2K
Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.2K

Area of Science:

  • Psychology
  • Oncology
  • Linguistics

Background:

  • A novel written exposure-based coping intervention (EASE) targets distress in advanced cancer patients.
  • EASE focuses on worst-case cancer scenarios to reduce trauma and fear of cancer progression (FoP).
  • This study investigates the linguistic mechanisms underlying EASE's effectiveness.

Purpose of the Study:

  • To examine how linguistic features of writing predict treatment outcomes in advanced cancer patients.
  • To identify specific writing patterns associated with reduced cancer-related trauma and FoP.
  • To explore the mechanisms of change in a written exposure-based intervention.

Main Methods:

  • Adults (N=28) with advanced cancer and elevated trauma or FoP participated.
  • Participants completed five weekly writing sessions (3 exposure, 2 coping).
  • Writing was analyzed using LIWC-22 linguistic software; outcomes assessed pre- and post-intervention.

Main Results:

  • Positive and negative emotion words in exposure writing predicted worse outcomes.
  • Increased death-related words during exposure writing correlated with reduced FoP.
  • Positive tone in coping writing predicted reduced FoP, while negative tone predicted worse FoP.

Conclusions:

  • Linguistic analysis provides preliminary support for proposed mechanisms of the EASE intervention.
  • Specific writing characteristics are linked to changes in trauma symptoms and FoP.
  • This research highlights the role of language in psychological interventions for advanced cancer patients.