Copper-mediated radiochemistry: historical impact, current trends, and future possibilities

Area of Science:

• Radiochemistry
• Radiopharmaceutical Development
• Medical Imaging

Background:

• Copper-mediated radiolabeling is a key technique in radiopharmaceutical chemistry.
• Its applications have expanded beyond initial preclinical studies.
• The field is evolving with new radionuclide incorporation and AI integration.

Purpose of the Study:

• To review the historical development of copper-mediated radiochemistry.
• To outline the current state-of-the-art in this field.
• To explore the future potential of copper radiochemistry in radiopharmaceutical development.

Main Methods:

• Literature review of copper-mediated radiolabeling techniques.
• Analysis of current applications in preclinical and clinical settings.
• Discussion of emerging trends, including AI-assisted development.

Main Results:

• Copper-mediated radiochemistry has successfully transitioned to clinical applications.
• The methodology supports various radionuclides, facilitating theranostic uses.
• Artificial intelligence is emerging as a tool to enhance radiochemistry development.

Conclusions:

• Copper-mediated radiochemistry is a vital and expanding area in radiopharmaceutical science.
• Its adaptability for different radionuclides and clinical translation highlights its significance.
• Future advancements, including AI, promise further innovation in theranostic agent development.