Related Experiment Video
Updated: Jun 15, 2025
07:12
Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method
Published on: August 2, 2021
3.5K
Dynamic Changes in ALFF and DC in Subthreshold Depression Before and After ICBT Intervention
Yu Wang1, Yuchen Ying2, Zili Zhu1
1Department of Radiology, THE First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, 315000, People's Republic of China.
Neuropsychiatric Disease and Treatment
|June 13, 2025
Summary
Subthreshold depression (SD) shows altered brain activity, particularly in the precuneus and insula. Internet-based cognitive behavioral therapy (ICBT) improved brain function in the hippocampus and medial frontal gyrus, correlating with symptom reduction.
Area of Science:
- Neuroscience
- Psychiatry
- Medical Imaging
Background:
- Subthreshold depression (SD) is a common precursor to major depressive disorder.
- Internet-based cognitive behavioral therapy (ICBT) is effective for SD, but its underlying neural mechanisms are unclear.
Related Concept Videos
01:30Electroconvulsive Therapy
29
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
29
01:03Long-term Depression
2.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.5K
01:25Cognitive Therapy
147
Cognitive therapy, pioneered by Aaron T. Beck in the 1960s, is a structured approach to addressing psychological distress by focusing on the influence of thoughts on emotions and behaviors. All cognitive therapies involve the basic assumption that human beings have control over their feelings, and that how individuals feel about something depends on how they think about it. Unlike psychoanalytic methods that delve into unconscious processes or humanistic approaches emphasizing...
147