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Updated: Jun 15, 2025
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Published on: March 15, 2024
Targeting ferroptosis with natural products in stroke: therapeutic mechanisms and translational opportunities
Yingyi Zheng1, Xi Tan1,2, Xiaojie Wang2
1The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China.
Abstract:
Ferroptosis is a new type of controlled cell death. It is distinguished by its reliance on iron and the production of lipid peroxidation. The role of ferroptosis in stroke has attracted a lot of attention recently. The purpose of this review is to clarify the connection between ferroptosis and stroke and to investigate the potential contribution of natural products to the clinical management of stroke and the discovery of novel medications. In this review, we summarize in detail the mechanism of ferroptosis after stroke, especially the relevant targets of ferroptosis after stroke. Furthermore, we summarize the natural products and herbal medicine currently employed in ferroptosis along with their mechanisms of action, highlighting the potential and challenges of clinical translation. We included 55 articles and classified them. After systematic screening, We think that ginkgolide B, kellerin, loureirin C, quercetin, icariside II, salvianolic acid A, berberine, Dl-3-n-butylphthalide is an effective candidate drug for the treatment of stroke.
Insights
Ferroptosis, a cell death pathway involving iron and lipid peroxidation, plays a key role in stroke. Natural products show promise for treating stroke by targeting ferroptosis mechanisms.
Area of Science:
- Biomedical Science
- Cell Biology
- Neuroscience
Background:
- Ferroptosis is a regulated form of cell death dependent on iron and lipid peroxidation.
- Emerging research highlights the significant role of ferroptosis in the pathophysiology of stroke.
Purpose of the Study:
- To elucidate the intricate relationship between ferroptosis and stroke.
- To explore the therapeutic potential of natural products in stroke management and drug discovery.
Main Methods:
- Systematic review and classification of 55 relevant scientific articles.
- Detailed summary of ferroptosis mechanisms and targets post-stroke.
- Analysis of natural products and herbal medicines impacting ferroptosis.
Main Results:
- Identified key ferroptosis mechanisms and targets relevant to stroke.
- Compiled a list of natural products and herbal medicines with ferroptosis-inhibiting properties.
- Highlighted specific compounds like ginkgolide B, berberine, and quercetin as potential stroke therapeutics.
Conclusions:
- Ferroptosis is a critical factor in stroke development.
- Natural products offer promising therapeutic avenues for stroke treatment by modulating ferroptosis.
- Several natural compounds demonstrate significant potential for clinical translation in stroke therapy.
