To Establish the Relationship between Proton Pump Inhibitors (PPIS) and Acute Interstitial Nephritis (AIN). Study...

Area of Science:

• Nephrology
• Clinical Pharmacology

Background:

• Proton pump inhibitors (PPIs) exhibit high utilization rates in India (45-85%), with 82.96% of chronic kidney disease (CKD) patients prescribed PPIs.
• Emerging case reports suggest a potential link between PPIs and acute interstitial nephritis (AIN), a rare adverse drug event.
• Establishing causality between PPIs and AIN is challenging due to polypharmacy in patients, complicating the identification of the specific offending agent.

Purpose of the Study:

• To investigate the potential association between proton pump inhibitor (PPI) use and the development of acute interstitial nephritis (AIN).
• To determine the incidence and clinical significance of PPI-induced AIN, particularly in patient populations with pre-existing chronic kidney disease (CKD).

Main Methods:

• Retrospective analysis of patient data to identify cases of AIN.
• Correlation of AIN onset with PPI initiation and dosage.
• Assessment of confounding factors, including concurrent medication use.

Main Results:

• Data analysis is ongoing to establish the relationship between PPI usage and AIN.
• The study aims to quantify the risk of AIN associated with PPIs.

Conclusions:

• Early recognition and drug withdrawal are crucial for preventing progression of AIN to end-stage renal disease.
• Further research is needed to confirm the causal relationship between PPIs and AIN.