Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

2.7K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.7K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

4.6K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reducing normalized mean square error during channel estimation using minimum pilot symbols in massive MIMO network.

Scientific reports·2026
Same author

Deterioration in Performance Metrics After Acute Achilles Tendon Ruptures in Elite Rugby Union Players: A Retrospective Sports Database Study.

Sports health·2026
Same author

Development and Evaluation of a Human-in-the-Loop Data Curation Training Program to Support a Digital Clinical Trial Platform: Descriptive Feasibility Study.

JMIR formative research·2026
Same author

H-Wave<sup>®</sup> Device Stimulation for Chronic Knee Pain Disorders: A Patient-Reported Outcome Measures Observational Study.

Medicina (Kaunas, Lithuania)·2026
Same author

Comparative Analysis of Microneedling With PRP Versus Vitamin C Serum in the Management of Post-Operative Cleft lip Scars.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·2025
Same author

Stem cell therapy for patients with paraplegia: is there hope for the future?

Expert review of neurotherapeutics·2025

Related Experiment Video

Updated: Jun 15, 2025

Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration
05:20

Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration

Published on: March 31, 2023

1.2K

Exosomes for the Management of Rotator Cuff Injuries: A Systematic Review.

Adarsh Aratikatla1, Shreya Arcot1, Manu Gupta2

  • 1School of Medicine, The Royal College of Surgeons in Ireland, Dublin, Ireland.

Indian Journal of Orthopaedics
|June 13, 2025
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cell-derived exosomes show significant regenerative potential for rotator cuff injuries (RCIs). Further clinical trials are needed to confirm their safety and effectiveness in treating these common musculoskeletal disabilities.

Keywords:
ExosomesExtracellular vesiclesMesenchymal stem cellsMusculoskeletal injuriesOrthobiologicsRegenerative medicineRotator cuff injuriesShoulder

More Related Videos

Large-Scale Preparation of Synovial Fluid Mesenchymal Stem Cell-Derived Exosomes by 3D Bioreactor Culture
09:48

Large-Scale Preparation of Synovial Fluid Mesenchymal Stem Cell-Derived Exosomes by 3D Bioreactor Culture

Published on: July 26, 2022

4.2K
Measuring 3D In-vivo Shoulder Kinematics using Biplanar Videoradiography
06:09

Measuring 3D In-vivo Shoulder Kinematics using Biplanar Videoradiography

Published on: March 12, 2021

3.0K

Related Experiment Videos

Last Updated: Jun 15, 2025

Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration
05:20

Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration

Published on: March 31, 2023

1.2K
Large-Scale Preparation of Synovial Fluid Mesenchymal Stem Cell-Derived Exosomes by 3D Bioreactor Culture
09:48

Large-Scale Preparation of Synovial Fluid Mesenchymal Stem Cell-Derived Exosomes by 3D Bioreactor Culture

Published on: July 26, 2022

4.2K
Measuring 3D In-vivo Shoulder Kinematics using Biplanar Videoradiography
06:09

Measuring 3D In-vivo Shoulder Kinematics using Biplanar Videoradiography

Published on: March 12, 2021

3.0K

Area of Science:

  • Regenerative Medicine
  • Biotechnology
  • Musculoskeletal Research

Background:

  • Rotator cuff injuries (RCIs) are prevalent global musculoskeletal conditions impacting daily life and work.
  • Current conservative treatments for RCIs have notable limitations.
  • Exosomes derived from mesenchymal stem cells (MSCs) are emerging as a promising therapeutic avenue.

Purpose of the Study:

  • To review the regenerative effects of MSC-derived exosomes on RCIs.
  • To compile findings from in vitro, preclinical, and clinical studies.
  • To catalogue ongoing clinical trials investigating exosome therapy for RCIs.

Main Methods:

  • Systematic literature search of four online databases (until March 2024) following PRISMA guidelines.
  • Inclusion of basic science, preclinical, and clinical research articles.
  • Identification of registered clinical trials from three international databases.

Main Results:

  • Included studies comprised four basic science, one basic science/preclinical, and twelve preclinical investigations.
  • Exosomes from various stem cells demonstrated potent regenerative capabilities for RCIs.
  • Growth factors and other pro-regenerative markers can potentially enhance exosome efficacy.

Conclusions:

  • In vitro and preclinical data support the regenerative potential of exosomes for RCIs.
  • Further clinical research is essential to evaluate the safety and efficacy of exosome-based therapies for RCI management.