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Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Preclinical Development: Overview01:28

Preclinical Development: Overview

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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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Evaluation of the teaching process enables the nurse to determine if the patient's learning needs were met and if training was effective. If the expected outcomes are not met, the care plan is revised, and additional education or reinforcement is provided. Nurses can ask questions after the session or obtain feedback to assess the patient's understanding of the topic.
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Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

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Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
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Nursing Clinical Information System01:27

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Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
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Related Experiment Video

Updated: Mar 27, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
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Development and Evaluation of a Human-in-the-Loop Data Curation Training Program to Support a Digital Clinical Trial

Mirna Issa1, Olivia Yang2, Jeffrey Doeve3

  • 1Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA, United States.

JMIR Formative Research
|March 25, 2026
PubMed
Summary

Trainees can curate oncology clinical trial data effectively using a structured training program. This approach supports the LookUpTrials platform by building a sustainable content pipeline for clinical trial navigation.

Keywords:
LookUpTrialscancerclinical trialsmobile appundergraduate students

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Area of Science:

  • Oncology
  • Clinical Informatics
  • Health Services Research

Background:

  • The LookUpTrials platform facilitates point-of-care navigation of oncology clinical trials using AI.
  • Sustaining high-quality, up-to-date trial data requires robust human infrastructure, which is underexplored.

Purpose of the Study:

  • To evaluate the feasibility of a structured training program for oncology clinical trial data curation.
  • To support the LookUpTrials digital platform through a supervised human-in-the-loop workflow.

Main Methods:

  • A descriptive feasibility evaluation of a cohort-based training and workflow model.
  • 10 undergraduate trainees curated trial data from institutional portals and ClinicalTrials.gov across 5 academic medical centers.

Main Results:

  • Trainees curated 2503 oncology clinical trial entries over 10 months, with increasing processing rates.
  • Participants found structured onboarding and peer support beneficial for engagement in data curation.

Conclusions:

  • Human-in-the-loop workflows for clinical trial data stewardship are feasible with untrained individuals, given proper training and quality assurance.
  • This study addresses the sustainability of the content pipeline for clinical trial knowledge tools, complementing previous work on platform integration.