Related Experiment Video
Updated: Jun 16, 2025

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients
Published on: December 16, 2022
A multidomain trial for cognition in women with cardiovascular disease
Shannon Halloway1, Michael E Schoeny2, Zoe Arvanitakis3
1Department of Biobehavioral Nursing Science, College of Nursing, University of Illinois Chicago, Chicago, Illinois, USA.
Introduction:
We evaluated the independent and combined efficacies of MindMoves (24-week physical activity and cognitive training) on cognition and serum neurotrophic biomarkers in older women with cardiovascular disease (CVD).
Methods:
This 2 × 2 factorial design randomized controlled trial (NCT04556305) tested efficacies of Mind (cognitive training) and Move (lifestyle physical activity) on change in cognition (global composite derived from three domains) and four serum biomarkers at baseline, 24, 48, and 72 weeks post-baseline in older women with CVD without cognitive impairment.
Results:
Of 253 participants randomized (mean age = 72.8; 57% non-Hispanic White), 87% completed the trial, though health-behavior adherence was low (Mind 45%, Move 33%). Interventions were not significant for global cognition. There were Mind x Move interaction effects for semantic memory and one biomarker, but these were counter to the hypothesized synergistic effects.
Discussion:
Mind and Move, alone or in combination, were not associated with improved cognition in this sample. Future research should emphasize adherence.
Clinical Trial Registration Number:
NCT04556305.
Highlights:
This trial evaluated the efficacy of a lifestyle intervention in women with cardiovascular disease. The trial did not show a significant difference in global cognition. There were significant effects of physical activity on secondary outcomes. Future research should focus on adequate intervention adherence and intensity.
More Related Videos
Related Concept Videos
Clinical Trials: Overview
Clinical Trials
There are four phases in a clinical trial. A phase one...
Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
Longitudinal Studies
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...

