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Updated: Jun 16, 2025

Deep Brain Stimulation with Simultaneous fMRI in Rodents
Published on: February 15, 2014
Robot-assisted deep brain stimulation with intraoperative CT imaging and frameless registration module: a new
Gonzague Defrance1,2,3, Philippe Domenech4,5,6, Johan Pallud1,2,3
1Department of Neurosurgery, GHU , Hôpital Sainte-Anne, Paris, France.
Background:
Although stereotactic frame-based techniques remain widely used for deep brain stimulation (DBS) implantation, robot-assisted procedures have demonstrated improved accuracy, enhanced precision, and reduced operative time. Our team has over two decades of experience in robot-assisted surgery and intraoperative imaging.
Method:
We detail our current surgical workflow for DBS implantation, combining the Neuromate robot (Renishaw), the NeuroLocate frameless registration module, and intraoperative cone-beam CT imaging using the O-Arm system (Medtronic).
Conclusion:
This approach provides a safe, efficient, and reproducible alternative to traditional methods, supporting its broader adoption in modern functional neurosurgery.

