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Association of anti-CarP levels with clinical activity and serological profile in rheumatoid arthritis
Pablo Martínez Calabuig1, Elena Grau García2, José Andrés Román Ivorra3
1Escuela de Doctorado en Ciencias de la Salud, Universidad Católica de Valencia, Valencia, Spain.
Objective:
To analyze the association of anti-CarP levels with clinical activity, manifestations, and serological profile in rheumatoid arthritis (RA) patients.
Methods:
Cross-sectional study including RA patients and healthy controls (HC). Clinical and analytical data were collected, and anti-CarP levels were measured by ELISA.
Results:
A total of 101 patients (79% female, mean age 45), and 98 HC (67% female, mean age 55) were included. RA patients had significantly higher anti-CarP levels than HC (p<0.001), increasing with age (p=0.004). Anti-CarP correlated with RF and ACPA positivity (p<0.001). Those patients with RF/ACPA positive showed the highest anti-CarP levels compared to other groups (p<0.001). The threshold for elevated anti-CarP was set at 17.2ng/mL. Among 35 patients with elevated anti-CarP, 32 were RF/ACPA double-positive (p=0.006), and 3 were seronegative. Elevated anti-CarP levels were associated to clinical activity, tender joints (p=0.002), the presence of rheumatoid nodules and interstitial lung disease, but not with Sharp/van der Heijde score, joint damage progression or Sjögren syndrome.
Conclusions:
RA patients exhibit higher anti-CarP levels, especially those with RF/ACPA double-positivity. Elevated levels correlate with higher disease activity and extra-articular involvement.
