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Related Concept Videos

In Vitro Fertilization01:24

In Vitro Fertilization

234
In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
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Infertility in Males01:23

Infertility in Males

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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Fresh vs. frozen donor oocytes in contemporary assisted reproductive technology.

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Assisted reproductive technologies in Latin America: the Latin American Registry, 2022.

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Corrigendum to 'International Committee for Monitoring Assisted Reproductive Technologies world report: assisted reproductive technology, 2019' [Fertil Steril 2025;124:679-93].

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International Committee for Monitoring Assisted Reproductive Technologies world report: assisted reproductive

Silke Dyer1, Georgina M Chambers2, Seung Chik Jwa3

  • 1Department of Obstetrics and Gynaecology, Groote Schuur Hospital and Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

Fertility and Sterility
|June 13, 2025
PubMed
Summary

Global assisted reproductive technology (ART) utilization increased in 2019, with more cycles and births reported. Key trends include greater use of embryo cryopreservation, single embryo transfers, and preimplantation genetic testing (PGT), leading to fewer multiple deliveries.

Keywords:
Assisted reproductive technologyinfertilitymultiple deliveriesregistrysingle embryo transfer

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Area of Science:

  • Reproductive Medicine
  • Biostatistics
  • Public Health

Background:

  • Assisted reproductive technology (ART) is crucial for treating infertility globally.
  • Understanding ART utilization, effectiveness, and safety is vital for patient care and policy.

Purpose of the Study:

  • To present the 2019 global data on ART utilization, effectiveness, and safety.
  • To analyze trends in ART procedures, including embryo cryopreservation and preimplantation genetic testing (PGT).

Main Methods:

  • Retrospective, cross-sectional survey using data from national and regional ART registries.
  • Analysis of cycle and pregnancy outcome data from 83 countries and 3,351 clinics.

Main Results:

  • Over 3.5 million ART cycles reported, resulting in over 783,000 infants born, an 8% increase from 2018.
  • Significant rise in frozen-thawed embryo transfers (61.8%) and freeze-all cycles (38.4%).
  • Preimplantation genetic testing (PGT) cycles increased to 6.6% of reported cycles, with a 4.2% multiple delivery rate.

Conclusions:

  • The 2019 ICMART report highlights increased ART utilization and improved outcomes.
  • Growing trends in embryo cryopreservation, single embryo transfers, and PGT are reducing multiple delivery rates.
  • The data provides a benchmark for ART trends prior to the COVID-19 pandemic.