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Related Concept Videos

Radiological Investigation I: X-ray and CT01:30

Radiological Investigation I: X-ray and CT

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Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
219

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Related Experiment Video

Updated: Jun 16, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Feasibility study on using low dose CT for adaptive proton therapy.

Sydney Shindler1, Tiezhi Zhang1, Tong Zhu1

  • 1Department of Radiation Oncology, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA.

Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists
|June 13, 2025
PubMed
Summary
This summary is machine-generated.

Low dose CT scans are feasible for adaptive proton therapy replanning, minimizing secondary radiation risks in pediatric patients. This approach maintains target coverage and organ sparing, offering a safer imaging alternative.

Keywords:
Computed tomographyLow doseProton

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Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Radiological Imaging

Background:

  • Adaptive proton therapy relies on daily imaging, but cone-beam CT (CBCT) has artifacts and inaccurate Hounsfield units.
  • In-room CT offers better image quality but poses concerns regarding cumulative radiation dose, especially for pediatric patients, due to secondary malignancy risks.

Purpose of the Study:

  • To investigate the feasibility of utilizing low-dose computed tomography (LDCT) images for online adaptation in proton therapy.
  • To assess the impact of reduced imaging dose on image quality and dosimetric accuracy.

Main Methods:

  • Evaluated 18 CT scan techniques on two quality assurance and three anatomical phantoms.
  • Scanned 10 proton therapy patients daily using conventional dose CT and two low-dose CT protocols.
  • Analyzed Signal-to-Noise Ratio (SNR) across different imaging dose levels and calculated dose distributions.

Main Results:

  • Signal-to-Noise Ratio (SNR) decreased with reduced imaging dose across all investigated techniques.
  • Dose calculations on low-dose CT scans showed minor variations in dose distributions for both phantom and patient data.
  • No clinically significant differences were observed in target coverage or organs-at-risk (OAR) sparing between conventional and low-dose CT scans.

Conclusions:

  • Low-dose CT scans are feasible for replanning in adaptive proton therapy, offering a potential reduction in cumulative radiation exposure.
  • Optimized low-imaging-dose CT protocols should be tailored to institutional practices and specific treatment sites to balance image quality and radiation dose.