Related Experiment Video
Updated: Jun 16, 2025
10:25
Author Spotlight: Integrating High-Resolution Intravital Imaging and MRI to Enhance Stereotactic Body Radiation Therapy Planning
Published on: April 12, 2024
1.3K
The Clinical Application and Significance of Contouring the Middle Cerebral Artery Under the Guidance of Three
Shuai Xu1, KeShuai Zhu1, Heping Zhou1
1Department of Neurosurgery, Anqing Medical Center of Anhui Medical University (Anqing Municipal Hospital), Anqing, Anhui Province, PR China.
World Neurosurgery
|June 14, 2025
Summary
3D-TOF MRA-guided middle cerebral artery contouring significantly improves insular glioma resection. This technique enhances tumor removal, reduces neurological deficits, and improves patient survival rates compared to traditional methods.
Area of Science:
- Neurosurgery
- Neuroradiology
- Oncology
Background:
- Insular gliomas pose surgical challenges due to proximity to critical neurovascular structures.
- Accurate delineation of the middle cerebral artery (MCA) is crucial for safe and effective tumor resection.
Purpose of the Study:
- To evaluate the clinical efficacy of middle cerebral artery (MCA) contouring guided by 3D-time-of-flight Magnetic Resonance Angiography (3D-TOF MRA) in the surgical resection of insular gliomas.
Main Methods:
- A retrospective analysis of 67 patients with insular gliomas treated between January 2017 and February 2021.
- Patients were divided into an observation group (3D-TOF MRA-assisted MCA contouring) and a control group (standard microsurgery).
- Comparison of extent of tumor resection (EOR), postoperative neurological dysfunction, Karnofsky Performance Status (KPS), progression-free survival (PFS), and overall survival (OS).
Main Results:
- The observation group achieved a significantly higher EOR (72.2%) compared to the control group (32.3%) (P < 0.001).
- Surgery-related neurological dysfunction was lower in the observation group (8.33%) versus the control group (35.6%) (P = 0.001).
- The observation group demonstrated improved 3-year PFS (31.6 months) and OS (33.5 months) compared to the control group (PFS: 15.3 months, OS: 19.8 months) (P < 0.05).
Conclusions:
- Preoperative 3D-TOF MRA effectively visualizes MCA anatomy, guiding surgical contouring of critical vessels.
- This approach facilitates safer and more effective insular glioma resection.
- The technique reduces postoperative neurological deficits and enhances long-term patient prognosis.
