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Genotoxicity Evaluation of Biokesum® Polygonum minus (Persicaria Minor) Standardized Extract Using Bacterial Reverse
Jennifer Ator1, Mitchell Kelly1, Rekha Shivaram2
1ToxServices LLC, Washington, District of Columbia, USA.
Abstract:
Persicaria minor is a shrub native to Southeast Asia that is commonly known as "kesum." Its leaf extract is used medicinally and in dietary supplements. To add to the overall toxicological dataset, Biokesum® Polygonum minus (Persicaria minor) standardized extract was tested in a battery of guideline genotoxicity tests, namely the OECD Guideline 471 bacterial reverse mutation test, the OECD Guideline 473 in vitro mammalian cell chromosomal aberration test, and the OECD Guideline 487 in vitro micronucleus assay. The use of multiple standardized, validated assays increases the overall predictive value relative to individual assays and provides greater confidence in the test results. All three assays were negative, demonstrating that Biokesum® is not genotoxic.
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