Metastatic Lymph Node Ratio in Right-Sided Colon Cancers Associated With Decreased Overall Survival

Area of Science:

• Oncology
• Gastroenterology
• Surgical Oncology

Background:

• Right-sided colon cancer prognosis is complex.
• Accurate prognostic factors are crucial for treatment planning.
• The role of metastatic lymph node ratio (mLNR) needs further investigation.

Purpose of the Study:

• To evaluate the effect of mLNR on overall survival in right-sided colon cancer patients post-curative resection.
• To compare mLNR with other prognostic variables.

Main Methods:

• Retrospective analysis of 129 right-sided colon cancer patients (2012-2017).
• Variables analyzed: age, sex, lymph node count, mLNR, disease stage, tumor location, morbidity.
• Statistical analyses: Kaplan-Meier, Cox regression.

Main Results:

• Higher mLNR (≥0.0801) was associated with significantly shorter overall survival (20.3 months vs. 106.6 months).
• Advanced TNM stage also correlated with reduced overall survival.
• mLNR and TNM stage were independent prognostic factors in multivariate analysis.

Conclusions:

• mLNR is a significant prognostic indicator in right-sided colon cancer, independent of lymph node yield.
• mLNR and TNM stage refine prognostic assessments for personalized treatment.
• mLNR serves as a practical tool for clinical decision-making.