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Related Concept Videos

In Vitro Fertilization01:24

In Vitro Fertilization

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In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...
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Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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Integration of Bioengineered Tools in Assisted Reproductive Technologies.

Aslı Ak1,2, Edith Coonen2,3, Ron van Golde2

  • 1Department of Cell Biology-Inspired Tissue Engineering (cBITE), MERLN Institue for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, 6229 ET, The Netherlands.

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Summary

Bioengineering innovations, including microfluidics and stem cells, are enhancing assisted reproductive technologies (ART). These advancements aim to improve fertility treatments from gamete handling to embryo implantation, offering personalized therapies.

Keywords:
assisted reproductive technologiesbioengineered platformsfertilizationimplantationin vitro modelsstem cell‐based embryo models

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Area of Science:

  • Reproductive Medicine
  • Bioengineering
  • Biotechnology

Background:

  • Infertility impacts approximately 17.5% of adults globally, creating significant challenges.
  • Assisted reproductive technologies (ART) are crucial for managing infertility.
  • Advances in bioengineering and reproductive medicine offer new solutions for ART.

Purpose of the Study:

  • To review microengineered and stem cell-based platforms for improving ART.
  • To synthesize current research on enhancing gamete handling, fertilization, embryo culture, and implantation.
  • To identify challenges and future directions for bioengineering in reproductive therapies.

Main Methods:

  • Review of microfluidic systems for sperm selection and processing.
  • Analysis of devices for oocyte handling and cryopreservation.
  • Examination of stem cell-based embryo models and bioengineered endometrial platforms.

Main Results:

  • Microfluidic devices show promise in sperm sorting and reducing gamete stress.
  • Specialized devices for oocyte processing and cryopreservation are emerging.
  • Stem cell models and bioengineered platforms aim to mimic in vivo reproductive environments.

Conclusions:

  • Microengineering and stem cell technologies offer potential to enhance ART procedures.
  • Further development is needed for broader application, especially in oocyte handling and embryo culture.
  • Addressing scalability, reproducibility, clinical validation, and ethical concerns is crucial for future progress.