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Updated: Sep 19, 2025

Intracranial Cannula Implantation for Serial Locoregional Chimeric Antigen Receptor CAR T Cell Infusions in Mice
Published on: February 24, 2023
Nanostrategies synergize with locoregional interventional therapies for boosting antitumor immunity
Ting Luo1,2, Kunpeng Ma3, Yi Zhang1
1Department of Interventional Ultrasound, Fifth Medical Center of Chinese People's Liberation Army General Hospital, Beijing, PR China.
Abstract:
Compared with traditional surgical resection, systemic chemotherapy, or radiotherapy, locoregional interventional therapies (LITs) possess their own advantages of minimally invasive procedure and immunomodulatory effects in cancer treatment. Local ablation and intravascular interventional therapy represent excellent LIT candidate to combine with immunotherapy. Diverse nanomaterials with excellent biocompatibility show promises in modulating antitumor immunity. In this review, we summarized several immune-LIT combinations, discussed the following immunomodulatory effects, and presented the novel nanostrategies for synergizing with the combination therapy. With continuous optimization, further promotion of clinical translation will ultimately benefit patients with personalized and tailored cancer strategy.
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