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Updated: Sep 19, 2025
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A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft
Published on: August 8, 2020
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Prior Organ Transplant Increases Risk of Wound Infection After Burn Injury: A National Database Study
Rebecca Hohsfield1, Hilary Y Liu1, David Orozco2
1Department of Plastic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
Summary
Organ transplant recipients with burn injuries face higher wound infection risks. This study highlights the need for specialized care to manage infections in these vulnerable burn patients.
Area of Science:
- Medical research
- Surgical outcomes
- Immunology
Background:
- Organ transplant recipients require immunosuppression, increasing infection and impairing healing.
- Burn injury management in transplant patients presents unique clinical challenges.
Purpose of the Study:
- To determine if a history of organ transplantation is an independent risk factor for wound infection in burn patients.
- To evaluate clinical outcomes in burn patients with and without a history of organ transplantation.
Main Methods:
- Retrospective case-control study using the Burn Care Quality Platform Registry (2013-2022).
- Identified 50 organ transplant recipients and matched them with non-transplant burn patients.
- Collected data on demographics, injury, surgical interventions, and outcomes.
Main Results:
- Transplant patients had a significantly higher wound infection rate (26% vs 6%, P = .006).
- No significant differences in hospital stay, ICU stay, ventilator days, surgical operations, or mortality.
- Organ transplantation history is a significant risk factor for wound infection in burn patients.
Conclusions:
- Burn patients with a history of organ transplantation are at a substantially higher risk for wound infection.
- Tailored management strategies are crucial for mitigating infection risk and optimizing outcomes in this population.
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