Association Between F-SIRI and Adverse Prognosis in Patients With Chronic Heart Failure

Area of Science:

• Cardiology
• Inflammation Biomarkers
• Prognostic Factors

Background:

• The Fibrinogen-Systemic Inflammation Response Index (F-SIRI) is a novel prognostic factor in gastric cancer.
• Limited data exists on the prognostic value of F-SIRI in chronic heart failure (CHF) patients.

Purpose of the Study:

• To investigate the correlation between F-SIRI and prognosis in hospitalized CHF patients.
• To explore the predictive value of F-SIRI for all-cause death, MACCEs, and cardiovascular death in CHF.

Main Methods:

• Retrospective cohort study of 1589 hospitalized CHF patients.
• F-SIRI calculated using (monocyte count*neutrophil count/lymphocyte count).
• Multivariate-adjusted Cox proportional hazard models used to assess outcomes.

Main Results:

• Higher F-SIRI levels were significantly associated with an increased risk of all-cause death (HR 2.37; p<0.001).
• F-SIRI improved prognostic ability for all-cause death beyond traditional risk factors.
• F-SIRI showed limited predictive value for MACCEs and cardiovascular death.

Conclusions:

• F-SIRI is a significant predictor of all-cause mortality in CHF patients.
• F-SIRI has limited predictive value for MACCEs and cardiovascular death in this cohort.