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Cardiac and systemic inflammation in cardiogenic shock
Guillaume Théry1,2, Nadia Aissaoui3, Olfa Hamzaoui1,2
1Intensive Care Unit, University Hospitals of Reims.
Current Opinion in Critical Care
|June 16, 2025
Summary
Cardiogenic shock (CS) involves complex cardiac and systemic inflammation, not just mechanical issues. Understanding these inflammatory pathways is key for risk-stratification and developing targeted therapies for CS patients.
Area of Science:
- Cardiology
- Immunology
- Critical Care Medicine
Background:
- Cardiogenic shock (CS) understanding has evolved from a purely mechanistic syndrome to a complex interplay of hemodynamic compromise and inflammation.
- CS is now recognized as a multifaceted condition with significant cardiac and systemic inflammatory components.
Purpose of the Study:
- To describe the involvement of cardiac and systemic inflammation in cardiogenic shock.
- To review current research on inflammatory biomarkers in CS.
- To discuss the implications of inflammation in risk-stratification and future therapies for CS.
Main Methods:
- This is a narrative review.
- The review synthesizes current literature on inflammation in cardiogenic shock.
- It examines inflammatory biomarkers and their role in risk stratification.
Main Results:
- CS is not a homogeneous entity; subphenotypes are crucial for patient management.
- Inflammatory biomarkers are increasingly important for risk stratification in CS.
- Identifying patient populations likely to respond to specific anti-inflammatory therapies is a key concern.
Conclusions:
- Cardiac and systemic inflammation are integral to cardiogenic shock pathophysiology.
- Inflammatory biomarkers offer potential for improved risk stratification and personalized treatment strategies.
- Future research and clinical trials are focusing on therapies targeting inflammation in CS.
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