Clinical data registry comparing outcomes of two light adjustable lenses

To compare the clinical performance of the light adjustable lenses (LALs) with the LAL+ with an increased central power to have broader depth of focus (DoF).

Private practice clinics.

Prospective, nonrandomized, nonmask, multicenter.

Clinical data collection registry of patients bilaterally implanted with the LAL or LAL+. Outcome measures included subjective manifest refraction; monocular corrected distance, intermediate and near visual acuity; binocular uncorrected distance, intermediate, and near visual acuity; and binocular uncorrected best focus visual acuity at differing contrast levels.

91.1% and 93.5% of LAL and LAL+ eyes had a manifest refraction spherical equivalent within 0.50 diopter of target, respectively. 92.0% and 89.0% of LAL and LAL+ patients had a binocular uncorrected distance visual acuity of 20/20 or better after adjustment, respectively. 86.0% and 93.0% of LAL and LAL+ patients had binocular uncorrected best focus visual acuity of J1 or better at 100% contrast, respectively. Distance corrected intermediate and near visual acuity was better with the LAL+ compared with the LAL, consistent with its further broadened DoF. Best corrected distance vision was only slightly reduced for LAL+ (1 letter), with both lenses achieving high levels.

Both LAL and LAL+ achieved excellent refractive and binocular visual outcomes at distance, intermediate, and near. The broadened DoF of the LAL+ was clinically evident and led to less anisometropia. The ability of patients to binocularly select and adjust their refraction according to their visual goal is a unique therapeutic approach to cataract refractive patients.