Pharmacology and function of the myoepithelial cell in the eccrine sweat gland

Both acetylcholine and a Ca-ionophore, A23187, are comparatively strong stimulants of eccrine sweat secretion in vitro. Nevertheless, the contraction of the secretory coil was seen only after stimulation with acetylcholine but not with alpha or beta adrenergic drugs or with A23187. It was thus inferred that the myoepithelial contraction may not be playing an indispensable role in the overall process of eccrine sweat secretion.