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Ultrasound-Guided Perineural Corticosteroid Injection for Lacertus Fibrosus Syndrome: A Retrospective Cohort Study
Cristóbal Greene1,2, Guillermo Droppelmann1, Nicolás García1
1Clínica MEDS, Santiago, Chile.
Orthopedic Research and Reviews
|June 17, 2025
Summary
Ultrasound-guided corticosteroid injections offer a minimally invasive treatment for lacertus fibrosus syndrome (LFS), improving nerve compression, strength, and pain. This approach provides a viable alternative for patients before considering surgery.
Area of Science:
- Orthopedics
- Neurology
- Radiology
Background:
- Lacertus fibrosus syndrome (LFS) involves proximal median nerve entrapment.
- Traditionally, surgical intervention was the primary treatment for LFS.
- This study explores a minimally invasive alternative.
Purpose of the Study:
- To evaluate the efficacy of ultrasound-guided perineural corticosteroid injections for LFS.
- To assess improvements in nerve compression, muscle strength, and pain.
- To determine if this injection is a viable alternative to surgery.
Main Methods:
- Retrospective quasi-experimental cohort study (July 2020-May 2023).
- Ultrasound-guided perineural corticosteroid injections administered to the lacertus fibrosus.
- McNemar test used for pre- and post-intervention data comparison.
Main Results:
- Significant improvements in muscle strength perception for key forearm muscles.
- Marked reduction in scratch test positivity.
- Notable decrease in reported pain levels.
Conclusions:
- Ultrasound-guided perineural corticosteroid injection is a safe and effective minimally invasive treatment for LFS.
- The procedure improves nerve function, strength, and pain.
- This technique offers a promising alternative to surgery for LFS patients.

